Belize is a relatively healthy country. Bottled water is a must in most areas. And, unless you eat only at tourist restaurants, dysentery may strike at some point; be prepared with over-the-counter medication and prescription antibiotics.
The CDC lists all of Belize except Belize City as a malaria risk area, and recommends the antimalarial drug chloroquine. Other drugs may also be recommended in certain circumstances - consult a qualified professional specialist.
Insect/mosquito bites should be prevented with appropriate clothing, repellents and insecticides, and bed nets if sleeping in non-air-con/unscreened rooms.
The sun, as anywhere else in the tropics, is very intense. A hat, high-SPF sunscreen, and sunglasses should do you fine.
Many places in Belize are very hot and humid, and dehydration is a risk. An expat suggests to drink as much water as you want, and then drink that much again.
The adult HIV/AIDS prevalence rate is currently at 2.5% or 1 per 40 adults.
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